                         SEQUENCE LISTING

<110>  Wyeth
       LaVallie, Edward R
       Collins-Racie, Lisa A
       Corcoran, Christopher J
       Agostino, Michael J
       Freeman, Bethany A
       Arai, Maya
       Flannery, Carl R
       Jin, Macy X
 
<120>  PROTEASES AND USES THEREOF

<130>  031896-034001 (AM101372)

<150>  US 60/562,687
<151>  2004-04-16

<160>  28    

<170>  PatentIn version 3.3

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Tyr Ile Glu Ala Ala Val Ile Pro Ala Gly Ala Arg Arg Ile Arg 
1               5                   10                  15      


Val Val Glu Asp Lys Pro Ala His Ser Phe Leu Ala Leu Lys Asp 
            20                  25                  30      


<210>  2
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  2
atgttccccg cccccgccgc cccccggtg                                       29


<210>  3
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  3
ggatcccccg aggcgctcga tcttgaact                                       29


<210>  4
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  4
ggatccggcc gggcgaccgg gggc                                            24


<210>  5
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  5
ctctagaagc tctgtgagat acatggcgct                                      30


<210>  6
<211>  65
<212>  DNA
<213>  Homo sapiens

<400>  6
ctctagacgg cgggcacgga gactgtctcc tggatgcccc tggtgcggcc ctgcccctcc     60

ccaca                                                                 65


<210>  7
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  7
acgtgtattt gacttttggg gggaagacct cgccagggac tgtcaggagc tgcactgtca     60

gaggctc                                                               67


<210>  8
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  8
cacacgttct ttgttcctaa tgacgtggac tttag                                35


<210>  9
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  9
gcggccgctc acagggggca cagctggctt tc                                   32


<210>  10
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Ser Gly Ser Ala 
1               5   


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  12
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  12
cttctagacg gcgggcacgg agac                                            24


<210>  13
<211>  82
<212>  DNA
<213>  Homo sapiens

<400>  13
ttctagagcg gccgccttat ttttcgaact gcgggtggct ccaagcagat ccggatccca     60

gggggcatag ctggctttcg ca                                              82


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
ggaccgctgc aagttgttct                                                 20


<210>  15
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  15
ggacacagat ggccagtgtt                                                 20


<210>  16
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  16
ccatcaatca ccttggcctc gaaca                                           25


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  17
ccacatcgct cagacaccat                                                 20


<210>  18
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  18
gcgcccaata cgaccaaa                                                   18


<210>  19
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  19
gggaaggtga aggtcggagt caacg                                           25


<210>  20
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  20
ggccagtgaa ttgtaatacg actcactata gggaggcggt tttttttttt tttttttttt     60

ttt                                                                   63


<210>  21
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Gly Gly Pro Leu Pro Arg Asn Ile Thr Glu Gly Glu 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Gly Leu Pro Leu Pro Arg Asn Ile Thr Glu Gly Glu 
1               5                   10              


<210>  23
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Gly Leu Pro Leu Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly 
1               5                   10                  15      


Ser Val Ile Leu Thr Val Lys 
            20              


<210>  24
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Ala Arg Gly Xaa Xaa 
1               5   


<210>  25
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  25

Asn Ile Thr Glu Gly Glu 
1               5       


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Ile Pro Glu Asn 
1               5   


<210>  27
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  27

Phe Phe Gly 
1           


<210>  28
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Leu Pro Ala Pro Ala Ala Pro Arg Trp Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Ala Arg Gly Ala Pro Ala Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Gln Ala Ser Glu Leu Val Val Pro Thr Arg Leu Pro 
        35                  40                  45              


Gly Ser Ala Gly Glu Leu Ala Leu His Leu Ser Ala Phe Gly Lys Gly 
    50                  55                  60                  


Phe Val Leu Arg Leu Ala Pro Asp Asp Ser Phe Leu Ala Pro Glu Phe 
65                  70                  75                  80  


Lys Ile Glu Arg Leu Gly Gly Ser Gly Arg Ala Thr Gly Gly Glu Arg 
                85                  90                  95      


Gly Leu Arg Gly Cys Phe Phe Ser Gly Thr Val Asn Gly Glu Pro Glu 
            100                 105                 110         


Ser Leu Ala Ala Val Ser Leu Cys Arg Gly Leu Ser Gly Ser Phe Leu 
        115                 120                 125             


Leu Asp Gly Glu Glu Phe Thr Ile Gln Pro Gln Gly Ala Gly Gly Ser 
    130                 135                 140                 


Leu Ala Gln Pro His Arg Leu Gln Arg Trp Gly Pro Ala Gly Ala Arg 
145                 150                 155                 160 


Pro Leu Pro Arg Gly Pro Glu Trp Glu Val Glu Thr Gly Glu Gly Gln 
                165                 170                 175     


Arg Gln Glu Arg Gly Asp His Gln Glu Asp Ser Glu Glu Glu Ser Gln 
            180                 185                 190         


Glu Glu Glu Ala Glu Gly Ala Ser Glu Pro Pro Pro Pro Leu Gly Ala 
        195                 200                 205             


Thr Ser Arg Thr Lys Arg Phe Val Ser Glu Ala Arg Phe Val Glu Thr 
    210                 215                 220                 


Leu Leu Val Ala Asp Ala Ser Met Ala Ala Phe Tyr Gly Ala Asp Leu 
225                 230                 235                 240 


Gln Asn His Ile Leu Thr Leu Met Ser Val Ala Ala Arg Ile Tyr Lys 
                245                 250                 255     


His Pro Ser Ile Lys Asn Ser Ile Asn Leu Met Val Val Lys Val Leu 
            260                 265                 270         


Ile Val Glu Asp Glu Lys Trp Gly Pro Glu Val Ser Asp Asn Gly Gly 
        275                 280                 285             


Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln Arg Arg Phe Asn Gln Pro 
    290                 295                 300                 


Ser Asp Arg His Pro Glu His Tyr Asp Thr Ala Ile Leu Leu Thr Arg 
305                 310                 315                 320 


Gln Asn Phe Cys Gly Gln Glu Gly Leu Cys Asp Thr Leu Gly Val Ala 
                325                 330                 335     


Asp Ile Gly Thr Ile Cys Asp Pro Asn Lys Ser Cys Ser Val Ile Glu 
            340                 345                 350         


Asp Glu Gly Leu Gln Ala Ala His Thr Leu Ala His Glu Leu Gly His 
        355                 360                 365             


Val Leu Ser Met Pro His Asp Asp Ser Lys Pro Cys Thr Arg Leu Phe 
    370                 375                 380                 


Gly Pro Met Gly Lys His His Val Met Ala Pro Leu Phe Val His Leu 
385                 390                 395                 400 


Asn Gln Thr Leu Pro Trp Ser Pro Cys Ser Ala Met Tyr Leu Thr Glu 
                405                 410                 415     


Leu Leu Asp Gly Gly His Gly Asp Cys Leu Leu Asp Ala Pro Arg Ala 
            420                 425                 430         


Ala Leu Pro Leu Pro Thr Gly Leu Pro Gly Arg Met Ala Leu Tyr Gln 
        435                 440                 445             


Leu Asp Gln Gln Cys Arg Gln Ile Phe Gly Pro Asp Phe Arg His Cys 
    450                 455                 460                 


Pro Asn Thr Ser Ala Gln Asp Val Cys Ala Gln Leu Trp Cys His Thr 
465                 470                 475                 480 


Asp Gly Ala Glu Pro Leu Cys His Thr Lys Asn Gly Ser Leu Pro Trp 
                485                 490                 495     


Ala Asp Gly Thr Pro Cys Gly Pro Gly His Leu Cys Ser Glu Gly Ser 
            500                 505                 510         


Cys Leu Pro Glu Glu Glu Val Glu Arg Pro Lys Pro Val Ala Asp Gly 
        515                 520                 525             


Gly Trp Ala Pro Trp Gly Pro Trp Gly Glu Cys Ser Arg Thr Cys Gly 
    530                 535                 540                 


Gly Gly Val Gln Phe Ser His Arg Glu Cys Lys Asp Pro Glu Pro Gln 
545                 550                 555                 560 


Asn Gly Gly Arg Tyr Cys Leu Gly Arg Arg Ala Lys Tyr Gln Ser Cys 
                565                 570                 575     


His Thr Glu Glu Cys Pro Pro Asp Gly Lys Ser Phe Arg Glu Gln Gln 
            580                 585                 590         


Cys Glu Lys Tyr Asn Ala Tyr Asn Tyr Thr Asp Met Asp Gly Asn Leu 
        595                 600                 605             


Leu Gln Trp Val Pro Lys Tyr Ala Gly Val Ser Pro Arg Asp Arg Cys 
    610                 615                 620                 


Lys Leu Phe Cys Arg Ala Arg Gly Arg Ser Glu Phe Lys Val Phe Glu 
625                 630                 635                 640 


Ala Lys Val Ile Asp Gly Thr Leu Cys Gly Pro Glu Thr Leu Ala Ile 
                645                 650                 655     


Cys Val Arg Gly Gln Cys Val Lys Ala Gly Cys Asp His Val Val Asp 
            660                 665                 670         


Ser Pro Arg Lys Leu Asp Lys Cys Gly Val Cys Gly Gly Lys Gly Asn 
        675                 680                 685             


Ser Cys Arg Lys Val Ser Gly Ser Leu Thr Pro Thr Asn Tyr Gly Tyr 
    690                 695                 700                 


Asn Asp Ile Val Thr Ile Pro Ala Gly Ala Thr Asn Ile Asp Val Lys 
705                 710                 715                 720 


Gln Arg Ser His Pro Gly Val Gln Asn Asp Gly Asn Tyr Leu Ala Leu 
                725                 730                 735     


Lys Thr Ala Asp Gly Gln Tyr Leu Leu Asn Gly Asn Leu Ala Ile Ser 
            740                 745                 750         


Ala Ile Glu Gln Asp Ile Leu Val Lys Gly Thr Ile Leu Lys Tyr Ser 
        755                 760                 765             


Gly Ser Ile Ala Thr Leu Glu Arg Leu Gln Ser Phe Arg Pro Leu Pro 
    770                 775                 780                 


Glu Pro Leu Thr Val Gln Leu Leu Thr Val Pro Gly Glu Val Phe Pro 
785                 790                 795                 800 


Pro Lys Val Lys Tyr Thr Phe Phe Val Pro Asn Asp Val Asp Phe Ser 
                805                 810                 815     


Met Gln Ser Ser Lys Glu Arg Ala Thr Thr Asn Ile Ile Gln Pro Leu 
            820                 825                 830         


Leu His Ala Gln Trp Val Leu Gly Asp Trp Ser Glu Cys Ser Ser Thr 
        835                 840                 845             


Cys Gly Ala Gly Trp Gln Arg Arg Thr Val Glu Cys Arg Asp Pro Ser 
    850                 855                 860                 


Gly Gln Ala Ser Ala Thr Cys Asn Lys Ala Leu Lys Pro Glu Asp Ala 
865                 870                 875                 880 


Lys Pro Cys Glu Ser Gln Leu Cys Pro Leu 
                885                 890 


